Comprehensive mapping of the human cytokine gene regulatory network
We are excited to share our latest publication “Comprehensive mapping of the human cytokine gene regulatory network”, a large-scale resource of protein-DNA interactions between human transcription factors and cytokine gene promoters. Clarissa and colleagues identified an enrichment of nuclear receptors which can be targeted with small molecules to modulate cytokine expression in the context of disease. This resource can also be leveraged to identify novel TF-cytokine regulatory axes in immune diseases and immune cell lineage development, as nicely illustrated in the paper published in Nucleic Acids Research. Read the paper here (https://doi.org/10.1093/nar/gkaa1055)!